More recently, screening of a total of 1729 polymorphisms across the whole HLA region in several independent Caucasian T1D datasets, revealed evidence of a secondary peak of association for T1D independent of known DQB1 and DRB1 effects, due to the HLA-B locus (Pcombined = 2.01 x 10-19) with the B*39 allele consistently associated with T1D and some evidence for an effect of B*18 [55]. Here, HLA-DRB1 is linked to type 1 diabetes mellitus.