Meta-analyses of the available data have suggested several of the genes belonging to either pathway to be involved in ADHD pathogenesis, including the dopamine receptors D4 (DRD4; 11p15.5) and D5 (DRD5; 4p16.1), SLC6A4, the dopamine transporter (DAT or SLC6A3; 5p15.3), the 5-hydroxytryptamine (serotonin) receptor 1B (HTR1B; 6q13), dopamine beta-hydroxylase (DBH; 9q34) and synaptosomal-associated protein of 25kDa (SNAP25; 20p12-p11.2) [reviewed in 36]. This evidence concerns the gene SLC6A3 and attention deficit-hyperactivity disorder.