The genes most often reported to be related to schizophrenia are the genes encoding disrupted in schizophrenia 1 (DISC1; 1q42.1), neuregulin-1 (NRG1; 8p12), dysbindin (DTNBP1; 6p22.3), D-amino acid oxidase activator (DAOA or G72; 13q34), D-amino-acid oxidase (DAO; 12q24), regulator of G-protein signaling 4 (RGS4; 1q23.3) and the dopamine-catabolizing enzyme catechol-O-methyl transferase (COMT; 22q11.21) [reviewed in reviewed in 18, 19]. The gene discussed is DISC1; the disease is schizophrenia.