CFHR5 and focal segmental glomerulosclerosis: It is noteworthy here that the presence of the CFHR protein, CFHR-5, has been detected in 92 out of 100 biopsies from patients with glomerular sclerosis from all causes, including diabetic nephropathy, focal glomerular sclerosis and advanced proliferative glomerular diseases with areas of sclerosis (Murphy et al., 2002).