We provide clear evidence that, at least in the two breast cancer cell lines that we have used in this current study, over-expression of PEA3 has a negative influence on Fgf-10 expression, consistent with our PEA3 knockdown data from endothelial cells, suggesting that PEA3 appears to act as a negative regulator of Fgf-10 expression. Here, FGF10 is linked to breast cancer.