FGF10 and craniosynostosis: Hypomorphic Fgf-10 mutations have been shown to cause lacrimo-auriculo-dento-digital (LADD) syndrome-like defects in both mice and humans (Rohmann et al., 2006; Shams et al., 2007), and FGF-10 has been implicated in the development of craniosynostosis (Ibrahimi et al., 2004; Wilkie et al., 2002).