NFKB1 and malignant colon neoplasm: These results are corroborated by a recent study in colon cancer cell lines, where p65 overexpression could sensitize the cells to curcumin effects [47], and by other reports suggesting that NF-κB might function as a pro-apoptotic or a tumor suppressor factor [47-49,52], depending on the nature of apoptotic stimuli or the cell type.