Although the accumulation of β-catenin could potentially be cancer-promoting, this did not rescue pancreatic cells from death due to lack of NF-κB activity, further supporting the importance of NF-κB activity in maintaining the survival of these cells, whereas Wnt/β-catenin appears to play a less prominent role in pancreatic cancer development [34]. This evidence concerns the gene NFKB1 and familial pancreatic carcinoma.