NFKB1 and familial pancreatic carcinoma: The exact role of GSK-3 in the maintenance of pancreatic cancer, the differential role of its isoforms in regulating NF-κB activity in these cells, and the mechanisms or conditions through which it maintains NF-κB activity remain unclear, although recent work suggests an important role for GSK-3 in the phosphorylation of IKK [39].