Finally, Grandgirard et al. compared daptomycin with ceftriaxone in an experimental model of rat pneumococcal meningitis; daptomycin more efficiently cleared pneumococci from CSF than did ceftriaxone, reduced the concentration of matrix metalloproteinase-9 concentration in CSF 40 hours after infection, and prevented development of cortical injury [11]. The gene discussed is MMP9; the disease is pneumococcal meningitis.