Moreover, unlike the conventional COX-2 inhibitors, celecoxib (Celebrex), rofecoxib (Vioxx), or other non-steroidal anti-inflammatory drugs, apigenin has vasorelaxing, anti-platelet, and anti-oxidant properties, which could reduce the risk of coronary disease and improve endothelial function [10-13]. The gene discussed is PTGS2; the disease is coronary artery disorder.