By inhibiting NF-kB activation, not only does apigenin inhibit the autoantigen-presenting and stimulatory functions of the APCs necessary for activation and expansion of autoreactive Th and B cells, but it causes apoptosis of the hyperactive lupus APCs (this study), probably by inhibiting NF-kB-regulated anti-apoptotic molecules, especially COX-2 and c-FLIP [5,6]. This evidence concerns the gene CFLAR and systemic lupus erythematosus.