Real time PCR revealed that infection of RRCECs with rAAV2-NTF2 resulted in significant upregulation of NTF2 mRNA (0.77±0.05 versus 0.51±0.02, p<0.01), In contrast, VEGF mRNA were significantly decreased in these cells (0.19±0.03 versus 0.28±0.03, p<0.01). The gene discussed is NUTF2; the disease is infection.