Up-regulated serum levels were observed for as many as nine proteins that play a role in coagulation (PLG, F9, F10, factor XII (F12), KNG1, PROZ, SERPING1 (serpin peptidase inhibitor, clade G, member 1), VTN, and FGG (fibrinogen gamma chain)), which may be relevant to the increased risk of venous thromboembolism and stroke with CEE. This evidence concerns the gene VTN and venous thromboembolism.