The deregulation of the PI3k/Akt/mTOR signaling axis in human cancers, the finding that ectopic expression of eIF4E is oncogenic [15], [16], and the demonstration that targeted down-regulation of eIF4E displays therapeutic benefit in xenograft mouse models [17] suggest that the process of translation initiation is a potential anti-cancer target. The gene discussed is EIF4E; the disease is cancer.