We have reported a similar finding among BRCA1 mutation carriers identified through unselected cases of breast or ovarian cancer (Warner et al, 1999; Moslehi et al, 2000; Gronwald et al, 2006) that is, among BRCA1 carriers, the risk of breast cancer was dependent on whether the affected relative had breast or ovarian cancer. This evidence concerns the gene BRCA1 and ovarian cancer.