MTOR and neoplasm: Indeed, phosphorylated mTOR has been generally found to be expressed in relatively low numbers of tumours, and several studies make no reference to tumour mTOR expression when assessing the effect of rapamycin and or its analogues (Jaeschke et al, 2002; Gao et al, 2003; Krishnan et al, 2006; El-Salem et al, 2007; Lu et al, 2008; Scheper et al, 2008).