In view of RPS6 being located in the same chromosomal region as CDKN2A (p16 (INK4)), a common tumour suppressor gene that is lost frequently in chordomas (Hallor et al, 2008), we speculated that the allelic loss of RPS6 correlated with the loss of CDKN2A. This was confirmed by showing that CDKN2A was detected by IHC in only 5 of 48 chordomas (Table 2) and that these 5 cases showed no evidence of allelic loss for RPS6. The gene discussed is CDKN2A; the disease is chordoma.