We also examined whether germ-line TGFBR1 mutations are responsible for the CRC susceptibility locus on chromosome 9 by screening the entire coding region of TGFBR1 in affected members of a large family with adenoma and CRC linked to chromosome 9q22.32-31.1 (Skoglund et al, 2006). The gene discussed is TGFBR1; the disease is adenoma.