TGFBR1 and colorectal carcinoma: In contrast to the findings of Valle et al (2008) in a large case–control study and meta-analysis of eight earlier published studies of the relationship between TGFBR1*6A and CRC, we found little evidence for the tenet that germ-line variation in the gene defined by this variant significantly influences CRC risk (Skoglund et al, 2007).