TGFBR1 and colorectal carcinoma: In some epidemiological studies, the TGFBR1*6A allele has been reported to be associated with an increased risk of a number of different malignancies, including CRC (Pasche et al, 1999; Chen et al, 2001; Baxter et al, 2002; Kaklamani and Pasche, 2005).