Similar results were observed in SBC-2-transfected cells (data not shown) Together, these results demonstrate that overexpression of CXCR1 or CXCR2 in SBC-2 and A375P melanoma cells leads to CXCL-8-induced activation of ERK1/2 MAP kinase, which facilitates increased cell growth and motility. Here, MAPK3 is linked to melanoma.