Similarly, the average number of TUNEL-positive cells in A375P-CXCR1 (36%) and A375P-CXCR2 (32%) were significantly lower as compared to A375P-control tumours (87%), demonstrating a 2.4-fold (A375P-CXCR1) and 2.7-fold (A375P-CXCR2) decrease compared to control tumours (Figure 3B, lower panel; Supplementary Figure 2B). Here, CXCR2 is linked to neoplasm.