MMP2 and cancer: Genes regulated by HIF1-α are key players in cancer development and include many angiogenic mediators (nitric oxide synthase and vascular endothelial growth factor (VEGF)), genes involved in cellular matrix metabolism (urokinase-type plasminogen activator receptor, matrix metalloproteinases-2 MMP2) and glycolysis (phosphoglycerate kinase-1 and lactate dehydrogenase; Weidemann and Johnson, 2008).