Also LDLR (low-density lipoprotein receptor, -2.83), DHCR7 (7-dehydrocholesterol reductase, -2.53) and HMGCS1 (3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1, -2.20) were downregulated in the cells derived from the HLS cases. This evidence concerns the gene VLDLR and Hydrolethalus.