For instance, recently, it was inferred that for certain flavonoids such as chrysin, nbiochanin A and apigenin a very low micromolar concentration is capable of producing 50% (EC50) of the maximum increase in mitoxantrone (MX) inhibitor substrate accumulation (interaction) with breast cancer resistance protein (BCRP), helping in reversing the multidrug resistance (MDR) mechanism of overexpressing MCF-7 MX100 cancer cells [51–54]. The gene discussed is ABCG2; the disease is cancer.