Based on the most important proteins, exemplified by the microtubule-associated tau, alpha-synuclein, amyloid-beta, or TAR-DNA binding protein-43 (TDP-43), diseases are classsified also as tauopathies, synucleinopathies, or TDP-43 proteinopathies. The gene discussed is TARDBP; the disease is proteostasis deficiencies.