ERBB2 and malignant colon neoplasm: This may be through a direct action causing downregulation of protein expression, as has been demonstrated in the HT29 colon cancer cell line [38], dissociation of HER2 from its chaperone, HSP90, as has been demonstrated in a gastric cancer model [57], or disruption of caveoli or lipid rafts, which has been recently demonstrated in response to CLA [58].