Activation occurs when the inhibitor of IkB, IκB-kinase (IKK) phosphorylates IκB, releasing NF-κB to migrate to the nucleus and regulate the expression of genes involved in tumor promotion and progression such as growth factors, cell cycle regulators, anti-apoptotic proteins, stromal remodeling proteases, angiogenic factors, and cell adhesion molecules [9], [11], [12], [13]. The gene discussed is NFKB1; the disease is neoplasm.