Second, we selected 6 genes from the microbicidal signature that were up-regulated in wt TG cells stimulated with P. aeruginosa products but not in stimulated CF-TG cells, namely the genes that encode CXCL10, IL-24, TLR2, IFNγR2, S100A8 and S100A9. This evidence concerns the gene S100A8 and cystic fibrosis.