Note that several transcription factors, including SP1, SP3 and CTNND1, were down-regulated in CF-TG cells compared to wt TG cells and that the SFTPB gene encoding the SP-B protein involved in the reduction of pulmonary surfactant properties [26] was up-regulated in CF-TG cells. The gene discussed is CTNND1; the disease is cystic fibrosis.