HSPB8 and cardiomyopathy: To clarify the functional role of HSPB8 induction on the development of HSPB5 R120G cardiomyopathy and test sufficiency, we generated a TG mouse, in which HSPB8 is overexpressed in a cardiac-specific manner using the inducible α-myosin heavy chain promoter [13] (Figure 5).