SENP8 and dengue disease: The sustained intervention program most likely averted the occurrence of major dengue outbreaks in Clorinda from 2003 to 2006 despite of the vicinity of endemic dengue transmission in Paraguay during the same time period; the large daily movement of people across the border; the invasion of the new DEN-3 serotype into Brazil, Bolivia and Paraguay since 2001–2002, and the very low herd immunity to DEN-1 and DEN-3 in the Clorinda population.