Three genes, CFLAR (CASP8 and FADD-like apoptosis regulator), COL3A1 (collagen type III alpha I) and ALS2CR2 (amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2, also called STRADB), showed differential expression in oesophageal biopsies from patients with GORD compared with healthy controls. The gene discussed is CASP8; the disease is lateral sclerosis.