IGF1R and obesity due to melanocortin 4 receptor deficiency: Hyperinsulinaemia has been linked to ventricular hypertrophy in obesity directly via the binding of insulin to myocardial insulin-like growth factor 1 receptors.[34] In this study, although insulin was seen to be a related to left ventricular mass on simple linear regression, it was not seen to be an independent predictor of left ventricular mass on multiple regression analysis.