BRCA1 and breast cancer: The E185Q SNP is located in a breast cancer carboxy-terminal (BRCT) domain (108–196 amino acids) of NBS1 [3], and such a domain facilitates NBS1 to interact with BRCA1 (one of two familial breast cancers mutated genes) forming BRCA1-associated genome surveillance complex (BASC), which is responsible for the recognition and repair of aberrant DNA [51].