There is now convincing evidence that a promoter polymorphism in the pro-inflammatory cytokine tumor necrosis factor (TNF) (TNF G-308A) is associated with increased risk for non-Hodgkin lymphoma (NHL) and specifically with the NHL subtype, diffuse large B-cell lymphoma (DLBCL) [1], [2]. This evidence concerns the gene TNF and non-Hodgkin lymphoma.