To address this gap in knowledge, we conducted a pooled analysis comprising three independent population-based case-control studies of NHL to investigate the etiologic relevance of common genetic variations in 48 genes (500 SNPs) encoding important members of the TNF and TNF receptor (TNFR) superfamilies, and NF-kB and related transcription factors, and I-kappa-B proteins and kinases critical for NF-kB activation and mediating its inhibition [7], [17], [18]. The gene discussed is TNF; the disease is non-Hodgkin lymphoma.