Mutations in distinct genes that encode the main cytoplasmic proteins of human lens have been associated with cataracts of various morphologies [18] including genes encoding crystallins (CRYA, CRYB, and CRYG) [19], lens specific connexins (Cx43, Cx46, and Cx50) [20,21], aquaporin (MIP) [22], cytoskeletal structural proteins (beaded filament structural protein 2 [BFSP2]) [23], paired-like homeodomain 3 (PITX3) [24], avian musculoaponeurotic fibrosarcoma (MAF) [25], and heat shock transcription factor 4 gene (HSF4) [26]. This evidence concerns the gene PITX3 and cataract.