Forthese reasons, studies in the field of PPAR are of high concern, not only tobasic researchers but also to clinicians for the management of liver diseases.This review will focus on (1) the liver injuries in HIV-infected patients; (2) both the current experimental and human data regarding PPAR and liver diseases; (3) the interactions between HIV and PPAR; (4) the potential use of PPAR agonists for the management of HIV-related liver diseases. The gene discussed is PPARA; the disease is liver disorder.