The potential role of PPARα in the development of liver steatosis is mostly based onexperimental data conducted in murine lacking PPARα.PPARα−/− mice displayobesity and serious liver steatosis without excessive food intake and PPARαactivation by fibrates reverses insulin resistance and reduces weight [40].There is a little data available in the human liver on PPARα liver expression and its rolein liver diseases. This evidence concerns the gene PPARA and liver disorder.