Ina murine model of intestinal cancer, adenomatous polyposis coli (APC)min/+ mice, it was shown thatthe TLRs and IL-1R, through the adaptor MyD88, control the signaling of manygenes which modify tumorigenesis in the intestine, including the NF-κB-mediatedgenes IL-6 and IL-1β [29].Loss-of-function studies demonstrated that MyD88-induced IL-6 wasnecessary for colon carcinogenesis [30]. Here, MYD88 is linked to intestinal cancer.