There are many possible intracellular or extracellular factors that could impact these parameters to create a heightened innate immune response: viral/bacterial infections [9], genetic variation in proteases/anti-protease or receptor activities [10], [11], other cytokines that raise innate immune baseline responses, or genetic variation or intracellular modulation of IL-8 production [12]–[14]. The gene discussed is CXCL8; the disease is bacterial infectious disease.