However, others have suggested either a potential contribution of Ala12 variant to hypertension [115] or an association of Ala12 allele with higher diastolic blood pressure in obese patients with T2D [150] while couple of studies fails to show an association between the PPARγ2 variant and hypertension [151, 152]. The gene discussed is PPARG; the disease is type 2 diabetes mellitus.