The obesity associated PNPLA3 variants rs12483959 and rs2072907 showed association with insulin sensitivity (Table 3) and disposition index (rs12483959: n = 264, GG: 122[66–208], GA: 109[61–214], AA: 74[52–197], β = −0.14, p = 0.017 and rs2072907: n = 265, GG: 121[66–209], GC: 109[58–215], CC: 83[56–192], β = −0.12, p = 0.043). This evidence concerns the gene PNPLA3 and obesity due to melanocortin 4 receptor deficiency.