No data are available on the use of ACE inhibitors and ARBs on atherogenesis in transgenic rats with inducible angiotensin II (Ang II)-dependent hypertension (TGR[Cyp1a1-Ren2]), two kidney-one clip (2K-1C) hypertension rats, or hypertensive double transgenic mice (R+/A+) that overexpress both human renin (R+) and human angiotensinogen (A+). This evidence concerns the gene REN and hypertensive disorder.