LPL and obesity due to melanocortin 4 receptor deficiency: Moreover, obesity and cardiac lipid accumulation has been associated with increased heart expression of genes that stimulate local production (i.e. lipoprotein lipase (LPL)) and transport protein mediated uptake (i.e., fatty acid translocase (FAT/CD36), fatty acid transporter protein 1 (FATP1) and fatty acid transporter protein 4 (FATP4)) of free fatty acids [5].