Our study has several strengths: (i) the study population is a well characterized group of baboons from the morphometric, biochemical and molecular standpoint with clear cut differences between the lean, insulin sensitive and the obese, insulin resistant baboons; (ii) this nonhuman primate model mimics closely findings in humans that relate the presence of a central obese phenotype with impaired glucose metabolism and insulin resistance, indicating the presence of the insulin resistance (metabolic) syndrome equivalent in the baboon [19-23]. The gene discussed is INS; the disease is Insulin resistance.