In summary, abdominal circumference is a major determinant of insulin sensitivity in both male and female baboons, and its association with fasting measurements of glucose metabolism and insulin sensitivity, i.e. FPI and FPG, provide a useful instrument to screen primates to identify insulin sensitive and insulin resistant for inclusion in large scale protocols designed to examine the effects of dietary and pharmacological interventions in the study of obesity, insulin resistance and type 2 diabetes in humans. Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.