Other cell-adhesion-molecular markers associated to lymph-node metastasis, as chemokine receptors CCR7, CXCR3 and CCL21 [40,41], could be related to brain metastasis development, thus, studies about analysis of their association with brain metastasis development are justified. This evidence concerns the gene CXCR3 and metastatic malignant neoplasm in the lymph nodes.