TNF and infection: In LMMs with untransformed TLR variables as the response, the predicted reductions in TNF-α production in mice in the highest louse infection category in relation to mice uninfected with lice were 49% for TLR2/HKLM, 55% for TLR2/zymosan, 59% for TLR9 and 56% for TIR (Table 2).