The tumour-associated trypsin inhibitor (TATI), synonymous with serine protease inhibitor Kazal type 1 (SPINK1) and pancreatic secretory trypsin inhibitor (PSTI; Huhtala et al, 1982), balances and inhibits trypsin specifically and may thus reduce tissue destruction (Wiksten et al, 2005). The gene discussed is CRISPLD2; the disease is neoplasm.