Pterygium formation has been reported to be related to dose of UV irradiation.[21] UV irradiation mainly produces DNA lesions between adjacent pyrimidines, and C to T transitions on dipyrimidine sites or CC to TT tandem mutations in the p53 gene are considered as the UV-related skin cancer molecular signatures.[22] Tsai et al.,[6] found that there was one case with a C to T transition, but no CC to TT tandem mutations in their 51 patients undergoing pterygium surgery. This evidence concerns the gene TP53 and skin neoplasm.