TP53 and neoplasm: Thus, they are almost undetectable by immune tests, including immunohistochemistry.[13, 14] Mutations in the p53 gene can lead to the synthesis of abnormal p53 proteins, which have altered conformations with loss of DNA binding[15] and complex to cellular proteins, resulting in prolonged half-lives and accumulation in the cells.[8] Accumulated mutant p53 proteins, which are often implicated as one of main steps in transforming altered cells into tumor cells, can then be detected, usually by immunohistochemistry, in neoplastic tissues.[8, 16]