Recently, Lyprinol has been shown to decrease the ability of lipopolysaccharide (LPS) to stimulate tumour necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) in splenocytes from a rat model of arthritis, where Freund's complete adjuvant containing Mycobactrium butyricum was injected into the paw [16]. This evidence concerns the gene TNF and arthritic joint disease.