Cav1 was detected in exosomes preparations derived from plasma of SCID mice engrafted with melanoma tumors by WB (Figure 3B), FACS (Figure 3C) and ELISA (Figure 3D) while Cav1 was undetectable in plasma-derived exosomes from control animals (Figure 3B, 3D). This evidence concerns the gene CAV1 and melanoma.