In agreement with previous results from melanoma and colo-rectal carcinoma (CRC) patients [10], [16], other tumor markers, such as MelanA/Mart-1 for melanoma and CEA for CRC, could be used for detecting the in vivo release of tumor exosomes in tumor-bearing SCID mice by Exotest, with results comparable with those obtained with Cav1. This evidence concerns the gene CAV1 and melanoma.