Both survival of wild-type and attenuated lpg− mutant parasites was equally enhanced in Stat1−/− PEMs between day 2 and day 5 post-infection (Figures 2A and 7B), suggesting that the pH-dependent activity compromised in Stat1−/− PEMs acts independent of LPG and its effects on oxidant resistance or phago-lysosomal fusion. This evidence concerns the gene STAT1 and infection.