HMX1 and Cone rod dystrophy: Although Hmx1 is expressed in the eye lens and retina during development, and the HMX1-deficient humans have a variety of ocular defects (microcornea, microphthalmia, anterior-segment dysgenesis, cataract, colobomata, abnormalities of the retinal pigment epithelium, and rod-cone dystrophy) the defects in mice appear restricted to microphthalmia.