SPI1 and acute myeloid leukemia: In the THP-1 model (an M5 monoblast like acute myeloid leukemia), we carried out systematic knock-down followed by expression profiling for a collection of 52 transcription factors (BCL6, BMI1, CBFB, CEBPA, CEBPB, CEBPD, CEBPG, CTCF, E2F1, EGR1, ETS1, ETS2, FLI1, FOXD1, FOXJ3, FOXP1, GATA2, GFI1, HOXA9, HOXA10, HOXA11, HOXA13, ID1, IRF7, IRF8, IRX3, LMO2, MAFB, MLL, MLLT3, MXI1, MYB, MYBL2, MYC, NFE2L1, NFKB1, NFYA, NOTCH1, NRAS, PTTG1, RUNX1, SNAI1, SNAI3, SP1, SPI1(PU.1), SREBF1, STAT1, TCFL5, TRIM28, UHRF1, YY1, ZNF238).