Our previous clinical study demonstrated that the levels of RhoA and RhoC mRNA transcripts in tumor tissues were significantly higher than those in the corresponding paratumor and normal tissues, and the expressions of both RhoA and RhoC in cancers with lymph node or liver metastasis were significantly higher than those in those without metastasis, indicating these two genes may contribute to the onset and development as well as invasion and metastasis of colorectal carcinoma. The gene discussed is RHOA; the disease is cancer.