LMNA and Emery-Dreifuss muscular dystrophy: In addition we also examined the expression of nuclear envelope proteins lamin A/C and emerin, mutations in which cause autosomal-Emery-Dreifuss muscular dystrophy (A-EDMD) [26] and X-EDMD [27] respectively, since there is evidence that these mutations may directly affect satellite cell function [reviewed in 28].