In order to further evaluate the potential benefits of mTOR inhibitor plus IFN-g combination therapy in the Tsc2+/- kidney tumor model, we compared single agent rapamycin treatment to rapamycin plus IFN-g treatment using a dosing schedule that includes daily treatment (five days per week) for one month before and after a period of weekly maintenance treatment for five months. Here, MTOR is linked to kidney neoplasm.