In contrast, in the fraction of infected cells, cytoplasmic-GAPDH remains constant (Fig 2B, lanes 1 to 6), while the nuclear-GAPDH increasing at 12 to 24 hours postinfection (hpi) and decreasing at 36 hpi were observed (Fig 2B, lanes 7 to 12) indicating that the nucleus-localized portion of GAPDH redistributed after viral infection. This evidence concerns the gene GAPDH and viral infectious disease.