Similar to our findings, downregulation of the 14-3-3 epsilon protein has been described in cervical carcinoma (Bae et al, 2005), and overexpression of 14-3-3 zeta in lung cancer cells (Qi and Martinez, 2003) and oral squamous cell carcinoma (Matta et al, 2007). Here, YWHAE is linked to oral cavity squamous cell carcinoma.