However, three proteins were significantly altered in vaginal cancer exclusively (DEAD box, erbB3-binding protein and biliverdin reductase), and six proteins in cervical cancer (peroxiredoxin 2, annexin A2, sarcomeric tropomyosin kappa, Rnas inhib chain A and prolyl-4-hydrolase beta). The gene discussed is ANXA2; the disease is vaginal cancer.