We underline as important the difference noticed between the upregulation of KLK10 in CRC shown in this work and its downregulation shown in previous studies and attributing it to CpG island hypermethylation, examining other cancer tissue types, like breast, prostate or ovarian (Sidiropoulos et al, 2005), gastric (Huang et al, 2007), head and neck (Worsham et al, 2006), testicular (Luo et al, 2001) and lung (Planque et al, 2008). This evidence concerns the gene KLK10 and cancer.